Q010 Patient temptation to discontinue antihypertensive therapy

The choice of antihypertensive therapy in the diabetic patient.

Arterial hypertension is common in patients with diabetes mellitus. In Type I diabetes, there is a significant increase in hypertension although, as would be expected, part of this association is due to the presence of diabetic nephropathy (Christlieb et al., 1981). In type II diabetics also, hypertension and diabetes are commonly associated and here obesity is the factor which could produce a ...

Antihypertensive Therapy

Effective antihypertonsive drug therapy began with the ganglion-blocking agents, followed by reserpine and hydralarine. later advances included the benzothiadiazine saluretic agents and more recently compounds which specifically inhibit the sympathetic nervous system, such as guanethidine, alpha-methyldopa, and certain amine oxidase inhibitors. Among the antihypertensive drugs, molecular modifi...

A Novel Approach to Antihypertensive Therapy?

Recently, novel corticotropin-releasing factor-related peptides, named urocortin 1, 2, and 3, and a distinct cardiac and peripheral vascular receptor (corticotropin-releasing factor receptor 2) were described being part of a peripheral corticotropin-releasing factor system modulating cardiovascular function in response to stress. Vasorelaxation and blood pressure lowering have been reported aft...

Impact of nonadherence to antihypertensive therapy.

The benefits of antihypertensive therapy in reducing cardiovascular complications have been impressive. Several clinical trials in hypertension have shown that reduction of blood pressure is associated with significant decreases in the incidence of stroke, ischemic heart disease, congestive heart failure, and renal failure, irrespective of age, gender, race or ethnicity, type of antihypertensiv...

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